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Bupinex Vet
Anesthetic Analgesic
(Code: 0026-0020)

Price:u$d 8,19

Long acting local anaesthetic and analgesic.
COMPOSITION
Bupivacaine Hydrochlorate 0.5%

• BUPINEX VET modern local anaesthetic that belongs to the Amidas group. Its extended action lasts 4 to 8 hours after application.

• Bupivacaine is 2 to 4 times stronger than Lidocaine, and it is safer as well.

• Its action starts between 3 to 20 minutes after application.

• BUPINEX VET is a watery injectable solution, which contains the equivalent to 5.0 mg of Bupivacaine Hydrochlorate every ml of sterile injectable solution.

• Bupivacaine is a new therapeutic tool; currently, it is very useful in Veterinary Medicine. It is a local anaesthetic agent, which allows working with safety and versatility; that is why it is the first choice in all kind of long minor surgical interventions with low or medium complexity.

• Its optimal anesthesic power keeps its powerful post-surgical anaesthetic effect.

BIOACTIVITY:

BUPINEX VET blocks the nerves' exciting conduction through neuronal membrane stabilization.

Membrane keeps in depolarization phase "0", blocking the nervous impulse transmission.

Pain is the first thing to lose and the last to recover.

BUPINEX VET allows an excellent post-surgical pain control due to its extended action.

DILUTIONS FOR SPECIFIC USE:

For every day vet practice, the suggested concentration is 0.50% Bupivacaine solution. This concentration allows using the agent to 0,5% or it will give -at the same time- the possibility of been diluted to 0,25%.

Bupivacaine 0.5% solution can be 0.25% diluted with physiological solution or sterile bidistilled water for injections.

Consider that when the drug is dissolved in water, the anaesthesia volume increases in tissues. It will not last so long, but its analgesic and anaesthetic effect will be the same.

It can also be dissolved in combination with half Bupivacaine (0.5%) and half Lidocaine (2%).

This combination reduces latency period due to Lidocaine quick action, thus increasing potency as well as anaesthetics and analgesics lasting effects.

DOSAGE:

BUPINEX VET could be applied using the same doses and volumes indicated for the use of Lidocaine Hydrochlorate.

The more injected analgesic volume at maximum concentration (0,50%), the more area will be numbed and the more lasting effect will be reached.

Reference general dose:

0,25 mg/kg of weight, equivalent to 0,05 ml/kg of weight.

In felines, it is suggested not to use more than 5 mg/kg of weight.

The orientation dose will depend on the requirements of the structure to be anesthetized and the kind of manoeuvre to make.

Tissues and structures anaesthesia to make manoeuvres in minor surgeries easy:

BUPINEX VET could be used in a dilution (0,25%) with water for injectable o with Lidocaine (2%).

Large nerve trunks blockade and anaesthesia:

It is recommended to use the original solution to 0,50%.

Peridural or subarachnoid anaesthesia:

Peridural anaesthesia is characterized by the regional blockade provoked by the anaesthetic, once injected in epidural area.

The mentioned blockade is produced in the spinal nerves, thus affecting the sympathetic, sensory and motor fibers.

This technique is indicated to carry out surgical proceedings in the epigastric area, hips orthopaedic surgery, perineum, back extremities, pelvis (rectum, vagina, bladder, and urethra), soft tissues in back extremities surgery, spinal analgesia, c-section surgery and obstetrical manoeuvres.

For this via, it is suggested to use the original concentration: Bupivacaine at 0,50%.

Maximum infusion velocity: 0,5 ml every 20 seconds.

Canines and Felines: 1 ml every 4,5 kg of weight. This dose could be reduced until 30% in overweight patients.

Porcine: 1,0 ml every 10 kg of weight.

Equines: Caudal anaesthesia: apply 5 to 7 ml BUPINEX VET (0,50%; 1 ml every 100 kg of weight) to reach a caudal anaesthesia with solution maintenance.

Exceeding this dose, is expected a decubitus due to cranial blockade.

Those doses should be reduced in old patients or when is planned an anatomic reduction of the spinal canal light. This precaution should be taken into account in order not to provoke a non-wished decubitus, due to a cranial blockade.

In equines, drug latency time -epidural via- is 10 to 30 minutes. This period of time is longer than in bovines because the adipose tissue in the spinal canal is more in equines than in bovines.

Usually, analgesic effect is prolonged during 60 to 90 minutes.

Bovines:

- Caudal anaesthesia: 8 to 10 ml total. Analgesic effect approximated duration: 2 hours.

- Cranial anaesthesia: when decubitus is necessary through this via, there should be used BUPINEX VET (0,50%) 50 to 60 ml total. In these cases, the animal should be immobilized during 3 to 4 hours to avoid its auto-trauma.

ADMINISTRATION:

Infiltration in tissues, IM, SQ, intra-articular and epidural injectable.

PRESENTATION:

Vials containing 50 ml of sterile injectable solution.

OBSERVATION:

BUPINEX VET is indicated for:

• Tissues and structures infiltrative local analgesia and/or anaesthesia (techniques: concentric, eccentric, deep, superficial and ring block).

• Epidural anaesthesia and/or analgesia. Unique and continuous dose.

• Intercostal nerves blocking.

• Intrapleural anaesthesia and/or analgesia.

• Intravenous regional anaesthesia (Bier blocking).

• Anaesthesia and/or infiltrative, intra and/or peri-articular analgesia.

• Regional or truncal nerve blocking, obstetrical, urogenital, correcting and ocular surgery

• Peripherical nervous blocking. Perineural, truncal and diagnostic multi-truncal anaesthesias.

BUPINEX VET should be administered with needle and hypodermic syringe, taking into account asepsis and antisepsis conditions to keep sterility in the product and structures to be injected.

COLLATERAL EFFECTS

- At indicated doses and frequencies, it does not show collateral effects.

- There were not found hypersensitive reactions regarding the drug.

- Histo-toxic and neuro-toxic damages have been described if the anaesthetic is applied neural and non-perineural via.

-It should be taken into account that –rarely- cases of patients reluctant to the local analgesic where observed, most of them, in epidural administration.

PRECAUTIONS:

-Do not use in infected tissues (abscess), traumatized areas or regions with pus, haematomas and/or effusion.

-It is not indicated as a topic anaesthetic nor as an anaesthetic to be used over mucous.

-Always, before tissues and/or structures drug infiltration, make the inhalation manoeuvre, corroborating –this way- not to administer the product through intravenous via.

-IV via is used exclusively for intravenous regional anaesthesia (Bier Block).

-Its iatrogenic administration through intravenous via could provoke symptoms such as bradycardia, dysrhythmia, ventricular fibrillation and hypotension.

WARNINGS:

-Do not mix in the same flask or syringe with any other compound different from the suggested to reach a reduction in the original concentration.

-Do not eat. Keep out of the reach of children.

-Keep the product between 4 and 25ºC, away from direct sunlight in a dry and hygienic place.

- Verify that the safety seal and the storage conditions before using the product are the adequate to its correct use.

-Doses and warnings are to be determined by the Veterinarian in charge.

Presentation: x 50 ml.
Action
Action: Anesthetic
Action: Analgesic
  • Quantity: 
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