Oxytocin 20 UI
C.s.p authorized excipients 1,0 ml
Suitable for big and small animals: cows, mares, sows, sheep, goats, female dogs and cats.
Indications for use:
Oxidil acts on uterine muscle in the following cases:
Induction of labour, uterine inertia or uterine atony, uterine involution after caesarean sections and decrease of bleeding.
Acceleration of lochia after birth or retained placenta.
Uterine contraction and rehabilitation after caesarean operation and control of uterine bleeding.
It helps to expel afterbirths, exuded after labour, and it stimulates milk’s way down to a gland in appropriate physiological conditions, agalactia of sows.
It optimizes the involution of the uterus after the birth of large fetuses.
Perimetritis and chronic endometritis to produce the removal of exudates.
Adjuvant treatment to the antibiotic therapy of acute and chronic mastitis.
Mode of action:
Oxytocin-based solution for injection, acts directly on smooth muscle of the uterus in all species, producing rhythmic and synchronic contractions.
It has been demonstrated in certain animal species, that cervix usually do not respond with contractions to the effects of oxytocin.
The degrees of uterine activity induced by the effects of oxytocin depend mainly on the stage of the reproductive cycle of the animal at the moment of administration.
The level of estrogens and progesterone, at the different stages of pregnancy, acts as the main control mechanism in the activity of this drug on the uterine muscle.
During the early stage of pregnancy the uterus is relatively insensitive to the action of oxytocin. It increases as the pregnancy comes to the end.
Oxytocin is the pure hormone of the posterior lobe of hypophysis, vasopressin-free and therefore free from hypertensive activity (it has no antidiuretic action), being its action completely selective.
Administered subcutaneously, it provokes, in a time of 10 to 20 minutes, of the muscle fibres of the uterus, intestine and breast acini. It has a tight activity in relation to milk letdown and its galactogogue effect
The mechanism by which milk discharge from the mammary gland is produced is still unknown, but it is supposed that oxytocin acts directly on certain elements of the smooth muscle in the mammary gland, such as myoepithelial cells surrounding the constituent alveoli of the gland.
An effect that has been proven is the ability of this substance to promote milk letdown. It s action is reinforced by the effects of calcium and estrogens.
Dosage, way and method of administration:
For obstetric use, oxytocin may be administered by the following routes: intravenous (IV), intramuscular (IM) or subcutaneous (SC), under appropriate aseptic conditions.