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Ionomax
Rehidratante Mineral
(Code: 0026-0014)

Price:u$d 8,58

New electrolyte therapy for maintenance, support and fluid replacement.
COMPOSITION
Sodium, Potassium, Magnesium, Chloride, Gluconate, Acetate, Dextrose.

- IONOMAX is a balanced electrolyte solution, ideal for replacing fluids and electrolytes in rehydration therapy, maintenance and support.

- In patients who need special medical care, the need for fluid depends on hydration status of it.

- For patients undergoing surgical treatment, additional indications for fluid therapy include maintenance of a permeable pathway, replacement of fluid loss by evaporation and / or bleeding and maintain optimal renal perfusion during anesthesia.

- Hydration status in animals is determined by evaluating your medical history, physical examination and laboratory results (cell volume, total protein concentration and urine specific gravity).

- The veterinary professional estimate the moisture deficits by evaluating the elasticity of the skin (fold maneuver), moisture of mucous membranes, eye position within the orbit, heart rate, peripheral pulse characteristics, filling time capillary and the existence of peripheral venous distention.

Pharmacokinetics
IONOMAX is distributed widely but not all electrolytes are distributed equally. It depends on the ionic charge of them, electroiónico state of the internal environment (plasma, extracellular and intracellular fluid), acid-base status of the internal environment, the volume of water in each of the different compartments of the protein content plasma and energetic state of the patient. The removal of ions occurs in the kidney.

Glucose is biotransformed to ATP for immediate use or used in glycogenesis to be stored.
A concentration of 2.5% glucose is almost impossible to overcome the renal threshold for the same, which is in dogs and cats 120 mg / dl in the plasma.
Sodium acetate is biotransformed in the liver and muscle to bicarbonate, acting as a precursor to it and contributing to the correction of acid-base imbalance of the internal environment. Sodium acetate is not used is eliminated by the kidney.

Drug Pharmacodynamics:
Solutes do not freely cross the membranes are responsible for generating the osmotic pressure. This osmotic pressure generated by the movement of water molecules within the internal environment.

• Sodium
Sodium is considered the backbone of extracellular fluid osmotic. IONOMAX contains electrolytes and nonelectrolytes, these components pass the intracellular fluid. The movement of these ions, governed by biophysical and biochemical principles, tend to restore the quantities, volumes and ionic charges of the different body compartments.

• Chlorine
Chlorine is the most abundant anion in the internal environment (extracellular fluid) and therefore of vital importance in replacement fluids.

• Magnesium
While their concentration is low, magnesium (Mg) is an important element in the composition of the solution. The dietary intake of both magnesium and potassium is restricted.

Functions of Magnesium in the internal environment:
- It is vital for cell homeostasis.
- Participates in the synthesis of ATP.
- Takes part in the operation of the pump Na / K (ATPase pump).
- It's regulator of potassium (K) intracellular.
- Spoke in the functioning of the calcium pump (ATPase pump).
- Acts in the synthesis of nucleic acids and proteins.
- Regulates the proton pump.
- Spoke as a second messenger in intracellular signal transduction.
- Regulates the vascular muscle tone.
- Enzyme cofactor for more than 70% of intracellular enzymes.

Scientific reports indicate 54% of critically ill patients are hypomagnesemic.

Between 36 and 61% of patients are refractory to treatment hipokalémicos if it does not provide correction of hypomagnesemia.

Magnesium losses are caused by:
- Digestive pathologies (short bowel syndrome, diarrhea, malabsorption, intestinal inflammation, liver cholestasis, anorexia): in these cases reduce the amount of it.
- Changes in the distribution of magnesium such as: parenteral or enteral nutrition without supplementation of trace elements, sepsis, trauma, hypothermia, pancreatitis, massive transfusion syndrome dilation, gastric torsion, etc.
- Loss of magnesium primary renal tubular disease, glomerulonephritis, acute tubular necrosis, obstruction or compensatory diuresis post post acute renal failure or chronic tubular damage by aminoglycosides, amphotericin B, carbenicillin, cisplatin, cyclosporine, etc.. Or extrarenal factors: thiazide diuretics such as furosemide or mannitol.

Other causes: use of digitalis, hyperthyroidism, primary hyperparathyroidism.
Mg supplementation dramatically reduces the frequency of arrhythmias in patients with slndrome traumatized and expansion, torsion, gastric volvulus (SDTVG)

• Potassium
Potassium is the major cation within the cell. The only source of income to the body is represented by the intake and excretion takes place via renal and fecal.
The acid-base disturbances can cause significant changes in potassium concentration of the internal environment. Hypokalemia occurs in patients with diarrhea, vomiting, intestinal inflammation, pancreatitis, polyuria, anorexia, etc. Potassium supplementation can be performed tactical when it knows the deficit in the internal environment or strategically when alterations are known only from the point of clinical and pathophysiological. In the latter case is indicated potassium supplement up to 40 meq / l of solution.

• Sodium acetate
Sodium acetate is biotransformed in the liver and muscle sodium bicarbonate, whose action is essential in the correction of acidosis.
The content of sodium acetate provides IONOMAX bicarbonate concentration similar to plasma.

• Glucose
The glucose content of the solution is not intended to provide energy in order to replace the nutritional value. Only meets the energy needs for the operation of diaphragm pumps are essential for the homeostatic restoration of the internal environment.

DOSAGE
Dosing Guidance:
- Dogs and Cats: 50-70 mL / kg / day.
Infusion rate: 7 mL / kg / hour.
- Calves and Foals: 60-80 mL / kg / day.
Infusion rate: 7 mL / kg / hour.

- Dehydrated Patients: You should add to the maintenance dose volume required to correct dehydration and contemporary losses.
These volumes will depend on the veterinarian's decision to use only IONOMAX acting or combined with other solutions, according to the requirements of the patient to be treated.
In puppies, the volumes should be increased to 50% due to greater total body water content.
It is recommended for 30% of the total dose calculated in the first hour and the remaining 70% within 4 hours.

- Interval between doses: it depends heavily on the evolution of the underlying disease. The fluid can be supplied on a continuous or split into two or three daily sessions in outpatients.

- Duration of treatment varies widely. Overall fluid therapy is not recommended more than five days without nutritional support.
The fluid should be discontinued when the state of hydration restored and the animal can maintain fluid balance through food and drink.

ADMINISTRATION:

EV, intraosseous or intraperitoneal Via

PRESENTATION:

530 mL Vials

OBSERVATION:

IONOMAX is a drug recommended for use in dogs, cats, calves and foals only.

It is formulated for use in the following cases:
- Maintenance Solution:
It is indicated to provide maintenance fluid intake in anorexic patients with inadequate intake of fluids, subjected to stress and as a contribution of fluid in the presurgical, transsurgical and postsurgical.

- Replacement of extracellular fluid loss:
IONOMAX Therapy Solution is indicated for fluid replacement in patients with polyuric stage renal failure, acute vomiting or chronic diarrhea processes, loss of third space fluid, trauma or dilation syndrome, torsion, gastric volvulus. Fluid replacement provided by IONOMAX improves kidney function and liver contribute to the correction of plasma pH.

- Support of plasma:
As a crystalloid solution helps to maintain plasma volume effectively.

- Alkalinization of plasma:
The content of sodium acetate provides an effective solution of sodium bicarbonate precursor in similar concentrations to those in plasma, achieving the same alkalinization effective in patients with mild to moderate acidosis.

- Dilution of extracellular fluid:
IONOMAX provides an effective means for the dilution of extracellular fluid after shock resuscitation with hypertonic solution of sodium chloride 7.5%.

- Replacement of contemporary losses:
It is effective for the replacement of contemporary losses caused by evaporation or perspiration, vomiting, diarrhea, loss to third space (pancreatitis, peritonitis) and internal redistribution of fluids.

Supportive Therapy in calves:
IONOMAX is effective as maintenance therapy for neonatal diarrhea of calves, of complex etiology (infectious and noninfectious), which occur both in the dairy herds and breeding during the first sixty days of life and causing serious economic losses, either by the deaths that occur, the cost of treatments and the decline in production.

Supportive Therapy in foals:
IONOMAX is the maintenance therapy of choice for foals dehydrated as a result of neonatal diarrhea caused by infectious agents, parasites, hormonal, nutritional and / or physiological causes.

The problem of electrolyte loss is doubled with the advent of the diarrheal syndrome, where the osmolarity decreases, resulting in an net loss of electrolytes into the small intestine.
Young animals are especially prone to a moisture deficits due to the increase of extracellular fluid.

The ability to conserve water decreases, the relationship between body weight and the area is large, being also the loss of fluids through immature skin very considerable.
Acute diarrhea in calves and foals are the leading cause of neonatal morbidity and mortality, resulting in significant moisture deficits, difficult to reverse without a good electrolyte therapy.

CONTRAINDICATIONS
IONOMAX is contraindicated in the following cases:
Severe hemolysis, oliguria, diabetic ketoacidosis, diabetes insipidus, extensive burns, poisoning with salt, hyperaldosteronism and hyperadrenocorticism.

PRECAUTIONS AND WARNINGS:
- The temperature of the solution should be between 18-20 º C at the time of administration.
- Check the animal's vital signs before and during his administration. Should be discontinued for adverse reactions noted.

- Must be performed during the infusion, careful monitoring of vital signs (heart function, lung, kidney, electrolytes).
- If the administration of the fluid is too fast, may have signs of fluid overload, evidenced by the presence of: serous nasal discharge, chemosis, tachycardia, coughing, abnormal breathing pattern, ascites, polyuria, exophthalmos, diarrhea, vomiting and edema of conjunctiva.

- In case of catheterization, the site is made it must be checked regularly and maintained in a hygienic manner, as well, should be monitored the patient's temperature.
- If a problem is verified septic, the catheter will be removed and placed in another way permeable.
- Due to the inadvertent administration of perivascular solution may cause a mild phlebitis to be the solution slightly hypertonic.

- During the infusion solution should be monitored cardiac function in search of bradyarrhythmias, if they appear but must reduce the rate of infusion. If it persists, discontinue administration.
- These arrhythmias are attributed to intolerance to the administration of the solution enriched with potassium.
- The maximum recommended dose of potassium is 0.5 mEq / kg / hour. The signs of hyperkalemia appear when the plasma potassium than 8 mEq / l.

- If the patient has any signs of hyperkalemia, such as bradycardia or ECG changes compatible (shortening of the QT interval, PR interval prolongation, reduction of the P wave or atrial standstill) must discontinue administration of the solution and start immediate treatment of hyperkalemia (Ca gluconate 10% 1-2 cc / kg / iv slow, dextrose 5 or 10% water + 0.55 to 1.1 IU / kg regular insulin or 2 g of dextrose for each IU of regular insulin, furosemide, 2-4 mg / kg).

- Caution when used in patients receiving any of the following drugs: propranolol, enalapril, captopril, spironolactone, amiloride, indomethacin, heparin. These drugs can cause hypernatremic states.
- In all cases, the dose and frequency of administration is by the veterinarian acting.
- Check that the inviolability of the product system and its storage conditions prior to use are adequate.
- The aluminum seal should not be removed. Only be removed or sealed flap (flip-off).

- In no way and under no circumstances must uncover the product, transfer or expose their contents to the environment, moves which threaten the preservation of the right and the inviolability of the pack.
- Keep the product between 4 to 30 º C, away from direct sunlight, rather than hygienic.
- Keep out of reach of children.

Presentation: x 530 ml.
Action
Action: Rehidratante
Action: Mineral
  • Quantity: 
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